A new technology on genome-wide DNA methylation profiling could improve the ability to predict disease progression and treatment outcomes of cancer, but also raises ethical and legal issues regarding, for example, autonomy, unsolicited findings, and the harms and benefits of screening tests.
More and more medical care can be provided remotely. This project identified factors that positively influence the trust that patients have in telecare innovations, and therefore their success.
This project proposes two tools for achieving a balance between surveillance by technological devices and control by / autonomy of patients and nurses with telecare applications.
More and better cognitive enhancement drugs are to be expected in the near future. When using those professionals could better improve or safeguard our health and security. Yet even if these drugs are effective and medically safe, they should not become the ‘new normal’ out of concern for people’s autonomy and freedom.
This project further develops a new EEG-based prognostic technology for comatose patients, identifying relevant socio-ethical values and how to pro-actively take them into account in the innovation process.
Patients who have run out of standard treatment options may get early access to investigational drugs. This project determines the ethical and societal conditions for a responsible design of services to facilitate early access.
“Digital Operation Room Assistant” DORA was designed to prevent technical errors in increasingly complex operation rooms. A clever design solved a dilemma that prevented DORA from being used effectively.
The developments taking place in the diagnosis of Alzheimer's are controversial. It is therefore high time that we examined how to achieve responsible innovation in this area.
Under which ethical, legal and societal conditions can biomarker tests be embedded in oncological and psychiatric healthcare? How can these conditions be taken on board in the further development of biomarker tests?
A system of national electronic patient records (Dutch acronym EPD) could improve the quality and efficiency of health care. A prerequisite for successful implementation is the confidence of healthcare providers in this system.
With the ageing of the population, the number of falls involving an elderly person is increasing. The result is a decrease in mobility and an increase in healthcare costs. Can innovation prevent this?
A great deal of attention is given to alternatives to animal testing, both in politics and in the health and life sciences sector. A new way of carrying out medical research projects could reduce animal testing while benefitting health and well-being.
Based on factors determining willingness to participate in health biobanks, this project develops new, responsible methods to enhance commitment and participation rates.
This project develops design guidelines to responsibly govern the institutional and ethical aspects of local bedside development and in-hospital production of personalised medicines.
Genome editing promises significant benefits for animal husbandry, but also raises important ethical and societal questions. This project aims to examine the conditions, if any, under which the technology can become embedded responsibly and acceptably in society.
Consumers over-use unhealthy products, while industry continues to supply these products. The researchers concluded that government should do more to stimulate easy access to the market for suppliers of healthy products, while at the same time improving the ability of consumers to make good choices by campaigns, education and easier access to information.
Lifestyle related diseases - like obesity, heart diseases and diabetes type 2 - form a major societal challenge. This project investigates the effectiveness of logos in preventing these diseases.
The rapid development of smartphone technology creates great opportunities for supporting a healthier lifestyle. This project develops ways through which users can trust health support systems and are willing to use them without this affecting their intrinsic motivation to lead a healthy lifestyle.
Palliative care at home is only possible in more complex cases if GPs are supported by palliative specialists. This project showed that this can be done in the Netherlands by using video consultation. Elderly patients had no trouble using the technology, and the contact was experienced as positive. One condition, however, is that there must be a clear distribution of responsibilities between care providers. In Nigeria, however, problems were encountered with this technology.
New digital technologies provide social and economic opportunities for the logistics of accommodating refugees. The researchers are developing an expert system to optimise the logistics process in a socially responsible manner, taking into account the ethical and social aspects and the interests of all stakeholders.
New design and business model approaches will enable Dutch companies to develop successful frugal water and health innovations in Africa, both from a commercial and a socio-ethical perspective. By collaborating with local entrepreneurs in Africa, Dutch companies can develop frugal innovations in a profitable manner.
Flames spewing from the kitchen tap, injection needles in our food. Some of the images traveling across the internet and social media can be frightening. We have to take them seriously and develop creative and informative new images together with supporters and opponents.
When existing medicines no longer offer a cure, people want new medicines as soon as possible. At the same time, they want the medicines to be safe. How should the “conditional approval” of medicines take place in a socially responsible way? There is currently the possibility of rapid, “conditional approval” of medicines for severe and as yet untreatable diseases. However, a medicine’s efficacy and safety must be monitored properly after it is put on the market. This project demonstrated that there is much to be gained by actively involving patients and physicians in the monitoring process. Success factors such as short lines of communication and a shared story about the desirability of the process were identified.
Thanks to new imaging techniques, we are able to understand more and more about how the brain works. However, responsible neuroimaging innovation requires a dialogue between science and society.